Metformin for Insulin Resistance in achieving weight loss: How long does it take to work?

December 22, 2011 by  
Filed under Common Questions

Question by Cassie: Metformin for Insulin Resistance in achieving weight loss: How long does it take to work?
I have been diagnosed with insulin resistance and have been prescribed 2500 mg metformin daily.

Many ppl with PCOS, metabolic syndrome, or insulin resistance lose weight bc their insulin isnt working properly without the aid of metformin or the like. I have been on it for over a week and have not lost any weight.

I was wondering if anyone has experienced weight loss after a couple weeks, rather than immediately.

Best answer:

Answer by drdebilitas
Hello ,

one week is a very very short period for metformin to work , it needs two weeks to reach the maximum effect , and more than 1 month to cause any weight loss ,

The action of metformin is greater when the patient starts a healthy diet simultanously , don’t forget that ,

2500 mg is a high dose to start with , and 1000 mg (in two doses ) would be better .


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One Response to “Metformin for Insulin Resistance in achieving weight loss: How long does it take to work?”
  1. says:

    Wow. I was prescribed that several years ago when I was about 16 years old. It seems that I was at 1000mg. I actually didn’t experience much weight loss directly from taking it. Of course, I was already exercising 3-4 hours per day and watching my diet (now that I know better, I was actually eating too little considering my exercise). Interestingly, I am actually far heavier now than I ever was back then since I was really sick with autoimmune problems for almost two years. However, I don’t have problems with my blood sugar anymore. I think I must have simply outgrown it.

    Anyhow, although some people definitely experience weight loss with this and other prescription drugs, I think it is important that you consider lifestyle choices that may affect your health. Depending on your situation, you may have developed insulin resistance due to being overweight, having poor nutrition, or being inactive. If these sorts of things resulted in your illness, you need to consider changing them.

    After all, the number on the scale isn’t directly related to good health. You need to consider exercise (strength, cardio, and flexibility) and nutrition (including carb/protein/fat, vitamins, minerals, antioxidants, and phytochemicals). It’s a lot to think about, I know, but that is what will let you live a healthy life. I am learning more about it every day, and am trying to get myself healthy again after having a long period of illness. In fact, I’ve started a blog to keep me accountable at . Feel free to stop by!

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